Enhancement of antibiotic production by co-cultivation of two antibiotic producing marine <i>Vibrionaceae</i> strains

ABSTRACT Deciphering the cues that stimulate microorganisms to produce their full secondary metabolic potential promises speed up discovery of novel drugs. Ecology-relevant conditions, including carbon-source(s) and microbial interactions, are important effectors metabolite production. Vice versa metabolites mediators in although exact natural functions not always completely understood. In this study, we investigated effects interactions in-culture produced antibiotics on production by Vibrio coralliilyticus Photobacterium galatheae, two co-occurring marine Vibrionaceae. co-culture, andrimid V. holomycin P. were, compared monocultures, increased 4.3 2.7 fold, respectively. Co-cultures with antibiotic deficient mutant strains (andrimid− holomycin−) did reveal a significant role for competitor's as stimulator own Furthermore, observed detoxifies sulphur-methylation. Results presented here indicate ecological competition Vibrionaceae is mediated by, cue for,